First and Last, 50 Year Old

first and last is a long running movie quiz about just what it sounds like it's about. Here's the first actual image...


or, if you prefer, the first post opening-credits image


and the (second to) last image ...prior to a close-up on the stars face so I can't show that!


and the first and last lines of dialogue if you still need help

first ~ [screaming] followed by "Look at me. Calm down. Calm down. What happened to the others?"
last ~ "Like a fifty year-old."

Can you guess the movie?*